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Discussion LD cases are rising globally, and there is no available human FDA-approved LD vaccine

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Critically, CL governs mitophagy quality control: Aberrant CL levels impair selective clearance of damaged mitochondria while activating NLRP3 inflammasomes and the cGAS-cGAMP-STING-TBK1-interferon regulatory factor 3 pathway, synergistically exacerbating dopaminergic neuron degeneration (156,157)